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however we cannot establish causality based on these retrospective results and further prospective investigations are needed. In the second study, researchers focused on examining how GLP-1 use might impact the risk of developing osteoporosis, gout, or osteomalacia (bone softening) in people with type 2 diabetes and obesity

However, the remarkable clinical success of GLP-1s brings forth critical challenges, most notably concerning cost and patient access

STEP-1 followed 1,961 people for 68 weeks and showed 14.9% average weight loss, while SURMOUNT-1 followed 2,539 people for 72 weeks and showed 20.9% average weight loss in the highest-dose tirzepatide arm