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Bcl2-family death agonists induce OMM permeabilization, thereby promoting cytochrome c release, whereas Bcl2-family death antagonists prevent it

doi:10.1016/s0140-6736(25)01185-7 14.A Research Study to Look at How Well CagriSema Helps People Living With Obesity Lose Weight and Maintain Weight Loss in the Long-term

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Phase 3 TRIUMPH-4 (NCT05931367) reported 28.7% body weight loss at 12 mg, 26.4% at 9 mg, vs 2.1% placebo at 68 weeks