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A phase III, randomized, double-blind, placebo-controlled trial, which was open-label for the comparator liraglutide group, evaluated dulaglutide monotherapy (0.75 mg) versus placebo versus once-daily liraglutide in individuals with T2DM

Blood testing for folate, homocysteine, and vitamin B12 is a good idea before starting therapy with GLP-1 receptor agonists

Other important safety information Do not use GLP-1s if you have a personal or family history of medullary thyroid carcinoma (MTC), multiple endocrine neoplasia syndrome 2 (MEN2), or pancreatitis

Its an incredibly effective preservative, but its efficacy isn't infinite, and it's certainly not invincible