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ER is extensively present in mouse skeletal muscle, and it is posited that estrogen may enhance muscle endurance by modulating muscle fiber composition via the ER signaling pathway (24)

33 It is thereby safe to say on the basis of published data, that absorption from the orobuccal route, for example by using oral dispersible film, is over 80% greater as compared to absorption from the gastrointestinal tract

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Moreover, the UA transportersURAT1, GLUT9, and ABCG2play crucial roles in regulating UA levels, with dysfunctional transporters leading to abnormal serum UA levels, as observed in hypouricemia and hyperuricemia