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The pathogenesis of coronary heart disease and other cardiovascular events includes stiffening of the arteries 34,48 , an effect that could be shown here to occur with JUUL use

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These aggregates have been implicated in several neurodegenerative diseases, such as amyotrophic lateral sclerosis, Alzheimers and Parkinsons, and also in cancer progression, emphysema, and chronic obstructive pulmonary disease

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