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Stage 4: Advanced gout (chronic tophaceous gout) This is a stage of chronic gouty arthritis, in which there are lumps of uric acid, or tophi (see Figure 2: Illustration of Toe Joint With Gouty Tophus ), frequent attacks of acute gout, and often a degree of pain even between attacks (see Figure 3: Progression of Gout )

A triple staining of CD4: FITC (CC8, IgG2a), CD8: Alexa Fluor 647 (CC63, IgG2a), and CD45 Ro : RPE (IL-A116, IgG3) was used to quantify memory T-cells

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