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Eli Lilly reports positive Phase 3 trial results for obesity drug retatrutide Published: 10:16 11 Dec 2025 EST Eli Lilly and Co (NYSE:LLY) reported positive topline results from its Phase 3 TRIUMPH-4 trial evaluating its obesity treatment retatrutide in adults with obesity and knee osteoarthritis

Semaglutide was associated with reduced alcohol consumption and blood alcohol levels during the laboratory drinking task Participants receiving semaglutide drank less (bar graph below) and achieved lower blood alcohol levels during the end of treatment alcohol self-administration paradigm

Beyond the average, the distribution of results is striking

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