Third, local effects in the gut may not require systemic absorption at all

decreased TSH, decreased Total T4, and decreased Free T4) Uncommon (0.1% to 1%): Galactorrhea, hypoadrenalism, diabetes insipidus [Ref] Local Very common (10% or more): Injection site pain (13.8%), injection site reactions Common (1% to 10%): Injection site hematoma [Ref] Dermatologic Very common (10% or more): Alopecia (13.2%) Common (1% to 10%): Pruritus, bruise, rash Uncommon (0.1% to 1%): Cellulitis, petechiae, urticaria, basal cell carcinoma [Ref] Musculoskeletal Common (1% to 10%): Joint pain, backache Uncommon (0.1% to 1%): Arthritis, joint effusion, muscle pain, Raynaud's phenomenon [Ref] Psychiatric Common (1% to 10%): Depression Uncommon (0.1% to 1%): Anxiety, paranoia, libido decrease [Ref] Other Very common (10% or more): Fatigue (31.8%), generalized pain (15%) Common (1% to 10%): Weakness Uncommon (0.1% to 1%): Hearing loss, otitis [Ref] Respiratory Very common (10% or more): Upper respiratory tract infection (18.2%), sinusitis (12%) Common (1% to 10%): Cold symptoms, flu symptoms, epistaxis Uncommon (0.1% to 1%): Pneumonia, pulmonary nodule, status asthmaticus [Ref] Renal Uncommon (0.1% to 1%): Increased creatinine kinase [Ref] Hypersensitivity Uncommon (0.1% to 1%): Allergic reaction Frequency not reported : Anaphylactic reaction [Ref] Immunologic Very common (10% or more): Antibodies to octreotide (25%) Ocular Common (1% to 10%): Blurred vision, visual disturbance Uncommon (0.1% to 1%): Increased intraocular pressure [Ref] Genitourinary Common (1% to 10%): Urinary tract infection, pollakiuria Uncommon (0.1% to 1%): Gynecomastia, amenorrhea, polymenorrhea, oligomenorrhea, vaginitis, nephrolithiasis, hematuria [Ref] References 1

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The utilization of serum folate and homocysteine tests and the prevalence of folate deficiency in reproductive-age Korean women during the COVID-19 pandemic