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It is a prevalent condition, impacting approximately 10% of women of reproductive age worldwideequating to around 190 million individualsand is highly associated with infertility, present in 3050% of women seeking infertility evaluation ( The pathophysiology involves complex interactions of endocrine, immunologic, and inflammatory processes, with retrograde menstruation as the most accepted theory for ectopic tissue implantation (6).Estrogen metabolism and chronic inflammation are key pathophysiological mechanisms, with emerging evidence highlighting the microbiomeparticularly the gut and genital tract microbiotain modulating estrogen metabolism and inflammation, potentially influencing disease etiology and symptomatology (7)

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It remains controversial whether melanosiscoli is associated with an increased risk for colorectal cancer

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1.8 Characterization and evaluation of genome edited plants Comprehensive characterization and evaluation are essential for validating the accuracy, stability, and effectiveness of genome-edited plants

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