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However, small-molecule 3 was quite lipophilic (logD 7.4 = 5.7), resulting in high metabolic intrinsic clearance in human liver microsomes (HLM) (CL int = 130 mL/min/kg, Table S4), which would likely lead to a short pharmacokinetic half-life (t 1/2 ) and the requirement for an unacceptably high daily dose in humans

Increased thirst is not listed amongst the common adverse effects in the Summary of Product Characteristics (SmPC) approved by the MHRA, though some patients do report experiencing thirst during treatment

Zinc also plays an essential role in sperm production and health, so a deficiency could prevent you from naturally conceiving children

doi: 10.1016/j.ijcard.2010.10.004