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(19:25): So that was the first hypothesis

It is a progressive condition eventually leading to kidney failure requiring dialysis or kidney transplantation and is associated with premature death, mostly from heart disease

Conversely, the release of cellular components or inflammatory signals following ferroptotic cell death can amplify immune responses, establishing a self-perpetuating immunometabolic crosstalk that may accelerate lesion progression and exacerbate tissue damage in OA

The blots were incubated with primary antibodies in 5% nonfat milk in Tris-buffered saline (TBS) with 0.05% Tween 20 (TBST) overnight at 4C