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Metformin can start working within hours to reduce blood sugar, while sitagliptin has a more gradual effect through boosting incretin hormones, reaching its full potential within 4-8 weeks

This benefit is especially significant in older adult populations, who generally demonstrate a weaker antibody response (seroconversion) to such immunizations (514)

doi: 10.1016/S0169-328X(03)00162-1 68 HwangD

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