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This distinction matters because it affects who the program is actually suited for

In patients with acquired HO, BBS, or POMC, PCSK1, or LEPR deficiency, there is insufficient information to characterize the ADA response to setmelanotide or -MSH and the effects of ADA on pharmacokinetics, pharmacodynamics, safety, or effectiveness of setmelanotide products

For people without deficiency, self-care should begin with basics that have stronger evidence: balanced meals, adequate protein, regular physical activity, hydration, sleep, and treatment of medical conditions that affect energy levels