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1 M DPI alone did not increase caspase activity, although higher doses are required to trigger caspase activation, as shown previously ( These results suggest that the cytotoxicity observed following treatment with MitoQ alone and in combination with DPI is not solely dependent on its ability to regulate mitochondrial superoxide production in MNA NB cells, which is in line with recent studies on MitoQ effects in other cancer cell types ( The arrested differentiation of neuroblasts is a characteristic of NB tumorigenesis and invasiveness ( Figure 1G )