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Key point: The dose difference between Ozempic and Wegovy is relatively small (2.0 vs
Overproduction of reactive species, including hydroxyl radical (OH), superoxide anion (O 2 ), hydrogen peroxide (H 2 O 2 ), hydroperoxides (ROOH), nitric oxide (NO), and peroxynitrite (ONOO ) may lead to protein/lipid oxidation and DNA mutation
GLP-1R expressed in the nucleus tractus solitarius signals to suppress appetite, delay gastric emptying and reduce body weight, and this is proposed to be mediated through PKA, decreasing phosphorylation of AMPK (89, 110)
Free Radic Biol Med (2015) 84:22745
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