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During the initial phases of tumor growth, M1-like macrophages, resembling TAM phenotypes in the TME, play a key role in tumor prevention by inducing antibody-driven cytotoxicity, producing ROS, and generating tumor necrosis factor (TNF) [60]

Mechanism of action L-Carnitine plays a central role in supporting mitochondrial energy production and reducing oxidative stress

Prevention of experimental allergic encephalomyelitis by various agents

Neurotoxicity is apparently dose-dependent (frequent for 250350 mg/m 2 , almost certain if dosage exceeds 500600 mg/m 2 ) [102], although cases of early onset have been described, particularly in patients with neuropathy risk factors [103]