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Outcome evidence requires controlled studies, defined endpoints, adverse-event reporting, and clear comparison groups [2], [3], [7]

Similarly, p-CREB levels were much higher in the hippocampi of BHBA-treated mice than in those of control mice (Figure 3E)

After 4 hours, the rate of clearance declined and plasma levels became more stable, exhibiting a relatively linear rate of decline suggesting a phase of pure elimination from 4 to 120 hours