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These medications work by mimicking the action of the naturally occurring GLP-1 hormone, which stimulates insulin secretion in a glucose-dependent manner, suppresses glucagon release, slows gastric emptying, and promotes satiety

The best injection sites for GLP-1 include the abdomen (around the navel), the front of the thighs, and the back of the upper arms

Various organic nanomaterials, including polymeric prodrugs and nanomicelles, provide stability and biodegradability but face challenges in clinical use because of complex synthesis

The combination of repulsion and steric constraints is thought to remove the X-Y linker from near the active site and relieve auto-inhibition