My legs did become weak yes & walking down any steps or stairs they would constantly shake, this started around 3 years ago, along with bumping into door frames & losing my balance etc
PMs have a threefold greater affinity for these phosphate groups than LPS, displacing the cations and thereby disrupting the organization of LPS and increasing the permeability of the OM [1, 22]
Garvey WT, Kuhlman AB, Rmer J, Pietilinen KH, Tvermosegaard KB, Lau DCW
Tirzepatide is the older, fully matured story: a single-molecule dual incretin agonist taken from discovery through Phase 1 proof-of-concept, [7] then through the large SURPASS (diabetes) and SURMOUNT (obesity) Phase 3 programs, and finally to FDA and EMA approval