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Translational concordance is strong: zebrafish SLC52A3 knock-down and SLC52A3 / mice recapitulate hearing loss, ataxia and early death, all of which improve with systemic riboflavin supplementation (17, 18)
REW enhances complement activation in an on-target manner Our structure-based approach did not only aim to improve engagement of human FcRn, but also the capacity to form Fc:Fc interactions in an on-target manner to facilitate hexamer Fc formation and complement activation 40 (Fig
Glucose transporters and ATP-gated K+ (KATP) metabolic sensors are present in type 1 taste receptor 3 (T1r3)-expressing taste cells
B12 has also been loosely linked to serotonin production, the brain chemical that promotes good moods and wards off depression
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