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To overcome these limitations, this review discusses a range of structural modifications, including N-terminal and C-terminal substitutions, fatty acid conjugation, and large molecule fusion technologies, which have collectively contributed to enhanced half-life, increased stability, improved receptor affinity, and retained or augmented bioactivity of GLP-1 analogs

A Phase 2 substudy released last year also confirmed the drugs strength in improving body composition

La monoterapia con Ozempic 0.5 mg y 1 mg una vez por semana durante 30 semanas result en reducciones estadsticamente superiores en la prueba de hemoglobina glucosilada (HbA1C) y el peso corporal en comparacin con el placebo (vase tabla 1)