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5.5 Conclusion and future direction Recognizing the limitations of conventional delivery routes in targeting the CNS, IN administration provides a non-invasive alternative that not only bypasses the BBB but also avoids hepatic first-pass metabolism

Given that the low-energy, low-metabolic activity state is central to antibiotic tolerance in multiple species, this screening may be adapted for other intracellular pathogens across various host cell types and will be agnostic to the mechanism responsible for tolerance 58,59,60,61

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The product undergoes rigorous quality control procedures to ensure purity, consistency, and potency across every batch