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Feature importance was assessed using mutual information, SHAP, and LIME, while pre-processing included normalization (Max Normalization) and handling outliers using the Interquartile Range (IQR) method 34

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To confirm this finding, we quantified the fluorescence of BSA treated cells by flow cytometry and found that the mean fluorescence intensity (MFI) of fluorescent BSA treated cells was reduced with previous cigarette smoke exposure (Fig 3C)