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In preclinical models, catestatin exhibits anti-inflammatory, antihypertensive, and metabolic effects, and reduced circulating levels have been associated with hypertension, obesity, and insulin resistance ( Despite these associations, catestatin has received limited attention as a therapeutic candidate, in part because it does not conform neatly to classical endocrine paradigms and lacks a single dominant receptor target

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Practical safety measures include routine lab tests and cardiovascular assessments under qualified supervision

doi: 10.1016/j.cell.2020.05.032 43 ThomasTStefanoniDReiszJANemkovTBertoloneLFrancisROet al