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It cleaves diverse types of protein precursors in the secretory pathway at downstream of basic-AA target sequence (canonically, R-X(R/K)-R) 335

A protein concentration of 1.0 g/mL and a mouse sera dilution of 1: 100 were the optimal conditions (Figure 2A)

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[2] The fibrosis-improvement difference was more modest and less clearly separated from placebo than the steatohepatitis-resolution difference an honest reading is that survodutide showed a strong signal on MASH activity and liver fat, and a more preliminary signal on fibrosis regression that will need the larger, longer Phase 3 trials to confirm