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Stack the two gaps together and the picture for the conventional protocol is unflattering: approximately one-fifteenth of the studied dose, delivered by a route that animal data suggest requires several-fold more peptide, targeting a compound whose dose-response may not be monotonic anyway

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To put this in perspective, the approval arrived nearly 300 days ahead of its original target date, setting a new record for the fastest review of a New Molecular Entity (NME) since 2002

Timing matters because glutathione competes with food amino acids for intestinal transport