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Ion transport mechanisms, including the plasma membrane Ca 2+ ATPase (PMCA) and anion exchanger 1 (AE1, Band 3), also function as checkpoints: PMCA extrudes excess Ca 2+ to limit overload, with its activity modulated by ceramide or AA, while AE1 mutations disrupting ion balance promote eryptosis (Nicolay et al., 2008

Comparably, in plants, the glycosylation of small molecules by glycosyltransferases (E.C

Additionally, MTX opposes thymidylate synthase [4]

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