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The logic is the synergy between the two pathways

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We postulated that 5FU treatment may promote an enhanced dependency on mitochondrial metabolism, and, in turn, mitochondrial metabolism may dictate sensitivity to 5FU

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Experimental models suggest TMAO may alter cholesterol metabolism, impair vascular function, and promote inflammation

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Free Radic Biol Med 94:135144 Ramyaa P, Krishnaswamy R, Padma VV (2014) Quercetin modulates OTA-induced oxidative stress and redox signalling in HepG2 cellsup regulation of Nrf2 expression and down regulation of NF-B and COX-2

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